Fri Mar 25 2022

10 articles - From Saturday Mar 19 2022 to Friday Mar 25 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Liver Transpl

Donor-recipient HLA-A mismatching is associated with hepatic artery thrombosis, sepsis, graft loss and reduced survival after liver transplantation.

In conclusion, HLA-A mismatching was associated with increased graft loss and mortality. The poorer outcome for The HLA mismatched group was due to hepatic artery thrombosis and sepsis and these complications occurred exclusively with HLA-A mismatched transplants. This suggests that HLA-A mismatching is important for post-transplant outcomes and knowledge of HLA-A status may enable enhanced surveillance and interventions to reduce risk of complications or stratified HLA-A matching in high-risk recipients.

Pubmed   Journal   ReadQx 

Preservation solutions for static cold storage in DCD and DBD liver transplantation in the United States.

There were no differences between groups among DCD LTs in the earlier eras, and among DBD LTs in al eras (all p-values >0.05). The latest US data suggests that HTK is at least non-inferior to UW for preserving DCD livers. These data support HTK use in DCD LT and contradict ILTS guidance.

Pubmed   Journal   ReadQx 

Pancreatology

Adjuvant therapy for margin positive pancreatic cancer: A propensity score matched analysis.

Patients with pancreatic cancer who undergo R1 resection have significant improvement in survival when treated with adjuvant chemoradiation and adjuvant chemotherapy. However, benefits were greater in those receiving adjuvant chemoradiation.

Pubmed   Journal   ReadQx 

Characterization of the deterioration of diabetes control in patients with a subsequent diagnosis of pancreatic cancer: A descriptive study.

Background Deterioration of diabetes control can be the first harbinger of pancreatic cancer. However, little is known about how to distinguish patients with pancreatic cancer-related diabetes deterioration from those with type 2 diabetes progression. We aimed to characterize the glycated hemoglobin (HbA after treatment intensification, and concomitant weight loss.

Pubmed   Journal   ReadQx 

Long-term outcomes of octogenarian pancreatic cancer patients treated with carbon ion radiotherapy.

C-ion RT in octogenarians with pancreatic cancer showed promising outcomes with acceptable acute and late toxicities and can be considered a reasonable alternative to radical surgery.

Pubmed   Journal   ReadQx 

Ribonucleotide reductase M2 subunit silencing suppresses tumorigenesis in pancreatic cancer via inactivation of PI3K/AKT/mTOR pathway.

Taken together, high RRM2 expression was associated with worse prognosis. Importantly, RRM2 knockdown deactivated PI3K/AKT/mTOR pathway, resulting in cell cycle arrest and/or apoptosis. This study shed light on the molecular mechanism of RRM2 in pancreatic tumor progression and is expected to provide a new theoretical basis for pancreatic cancer treatment.

Pubmed   Journal   ReadQx 

Somatostatin analogues for the prevention of pancreatic fistula after open pancreatoduodenectomy: A nationwide analysis.

Use of lanreotide in al patients undergoing pancreatoduodenectomy has a potential protective effect on POPF development. Protocols for HR patients only might be favorable too. However, future studies are warranted to confirm these findings.

Pubmed   Journal   ReadQx 

The course of acute pancreatitis in patients with different BMI groups.

Although complications, mortality, longer hospitalization, and interventional procedures were observed more in the overweight and obese, successful prediction of Atlanta severity and Balthazar-CTSI scores based on BMI does not appear to be accurate. OB carries an increased risk for morbidity and mortality. The combined effects of risk factors increased mortality, longer hospital stays, and ICU admission.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Letters&Replies

Letters to the editors and authors’ replies

Liver Transpl

Acute cellular rejection in liver transplant recipients following COVID-19 vaccination.

Pubmed   Journal   ReadQx 

Pancreatology

Pancreatic Castleman's disease: Ring of fire sign and endoscopic ultrasonography guided fine-needle biopsy helps preoperative diagnosis.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…